| producto_id | tipo_produccion_id | idioma_id | anio_publica | titulo | resumen | palabras_clave |
| 2 | 1 | 4 | 2015 | Evaluation of the antiemetic efficacy of maropitant in dogs medicated with morphine and acepromazine | Objective To evaluate whether maropitant(1 mg kg1) injected subcutaneously (SC), administeredsimultaneously or 30 minutes prior to intramuscular(IM) administration of morphine(0.5 mg kg1) and acepromazine (0.05 mg kg1),reduces the incidence of salivation, retching andemesis in dogs.Study design Randomized, controlled, prospectiveclinical trial.Animals Sixty dogs scheduled for an ovariohysterectomyas part of a population control program.Methods Dogs were randomly allocated to beadministered maropitant (1 mg kg1) SC simultaneously(group M0) or 30 minutes prior to (groupM30) administration of morphine (0.5 mg kg1)and acepromazine (0.05 mg kg1) IM. A controlgroup was administered normal saline (C) at T-30and T0. Dogs were observed for 30 minutes aftermorphine?acepromazine administration. The occurrenceof vomiting, retching and salivation wererecorded, as well as the time to first emesis and thenumber of emetic events per dog.Results The occurrence of salivation was not differentbetween the groups. Retching and vomitingoccurred significantly less frequently in M30 than inthe other two groups (p < 0.02). The number ofemetic events was also significantly less for M30than for the other two groups (p = 0.01). Whenemesis occurred, the time to the first emetic eventwas similar among the groups.Conclusions and clinical relevance Maropitant(1 mg kg1) SC reduced the frequency of morphine-induced emesis by as much as 70% whenadministered 30 minutes in advance. Simultaneousadministration of maropitant and morphine?acepromazineproduced no measurable effect on thefrequency of retching or vomiting. | Maropitant|Morphine|Acepromacine|Vomiting|Dogs |
| 3 | 1 | 5 | 2015 | Economía social y acción colectiva. El caso de la economía barilochense de pequeña y micro-escala | El desarrollo es un proceso endógeno de creación de riqueza y mejores condiciones de vida de la población, donde los procesos de acción colectiva entre actores públicos y privados de un territorio y sus mecanismos institucionales son un factor clave. El trabajo articula enfoques teóricos del desarrollo local, acción colectiva y economía social. La hipótesis es que, frente a situaciones de catástrofe, los esfuerzos y compromisos colectivos, como manifestaciones de capital social, podrían potenciarse y convertirse en estrategias de superación de la crisis y de desarrollo. Se analizan los procesos asociativos entre microemprendedores de la ciudad turística de Bariloche (Patagonia Norte, Argentina) que surgieron o profundizaron con la emergencia volcánica de junio-2011. La evidencia empírica muestra que la crisis (factor exógeno) expuso la vulnerabilidad e invisibilizacion del sector dando luz a nuevas oportunidades. Promover y fortalecer el capital social (factor endógeno) resulta estratégico para pensar políticas de desarrollo local. | CAPITAL SOCIAL|EMPRENDEDORES|DESARROLLO LOCAL |
| 4 | 1 | 4 | 2015 | Prosopis alba exudate gum as excipient for improving fish oil stability in alginate?chitosan beads | The aim of the present work was to employ an exudate gum obtained from a South American wild tree (Prosopis alba), as wall material component to enhance the oxidative stability of fish oil encapsulated in alginate?chitosan beads. For this purpose, beads were vacuum-dried and stored under controlled conditions.Oxidation products, fatty acid profiles and lipid health indices were measured during storage. Alginate?chitosan interactions and the effect of gum were manifested in the FT-IR spectra. The inclusion of the gum in the gelation media allowed decreasing the oxidative damage during storage in comparison to the free oil and alginate?chitosan beads. The gum also improved wall material properties, providing higher oil retention during the drying step and subsequent storage. Fatty acids quality and lipid health indices were widely preserved in beads containing the gum. Present results showed a positive influence of the gum on oil encapsulation and stability, being the main mechanism attributed to a physical barrier effect. | PROSOPIS ALBA|EXUDATE GUM|DHA|IONIC GELATION |
| 7 | 1 | 4 | 2015 | Annexin A2 and S100A10 in the mammalian oviduct | In many mammals upon entryon the female reproductive tract a subpopulation of sperm is stored in theoviduct forming a functional reservoir. In the oviducts of pig and cow, AnnexinA2 (AnxA2) has been linked to the binding of sperm. This protein may exist as a monomer or boundto S100A10, and both forms are associatedwith different biological functions. S100A10 has not yet beenreported in the oviduct. The objective of this work was to analyze for thepresence of S100A10 in the oviduct and advance in the study of AnxA2 andS100A10 in this organ. This work shows the presence of both proteins, AnxA2 andS100A10, in the oviduct of human, pig, cow, cat, dog and rabbit. At least in pig,AnxA2 is found devoid of S100A10 in the outer surface of the apical plasmamembrane of oviductal epithelial cells, indicating it binds to sperm as a monomer or in association with proteins differentfrom S100A10. In the apical cytoplasm of pig oviductal epithelial cells, AnxA2 isassociated to S100A10. Inprimary culture of porcine oviductal cells, the expression of ANXA2 is increased byprogesterone, while the expression of S100A10 is increased byprogesterone and estradiol. Thewidespread detection of both proteins in the oviduct of mammals indicates a probable conserved function in this organ. In summary, S100A10and AnxA2 are widespread in the mammalian oviduct, but AnxA2 would bind sperm invivo devoid of S100A10 and may be related to reservoir formation. | oviducto|anexina A2|S100A10|reservorio |
| 9 | 1 | 4 | 2015 | Mechanochemical synthesis of MnZn ferrite nanoparticles suitable for biocompatible ferrofluids | Mn0.4Zn0.6Fe2O4 nanoparticles (NPs) were synthesized by the mechanochemical method, starting from elemental oxides. Structural and magnetic properties of the NPs were investigated by X ray diffraction (XRD), vibrating sample magnetometry (VSM) and both scanning and transmission electron microscopy (SEM and TEM). XRD measurements show that MnZn ferrite is already present after 15 min of milling. After milling for 120 min, the resulting powder is almost completely single-phase without the need of any thermal treatment. Magnetization curves for samples with different milling times show saturation magnetizations ranging from 12.2 emu/g ?after 15 min to 50.3 emu/g ?after 120 min. Coercive field and remanent magnetization are negligible for all samples, in agreement with a superparamagnetic behavior. NPs with mean size of 8 nm were separated by centrifugation and were coated with chitosan for the preparation of a ferrofluid, which showed good stability for 12 h. The Intrinsic Loss Parameter (ILP) of this fluid indicates that the mechanochemical method can be a good alternative for the synthesis of the usual Fe-oxides ferrofluids used in hyperthermia. | MECHANOCHEMISTRY|MNZN NANOPARTICLES|BIOCOMPATIBLE FERROFLUIDS |
| 10 | 1 | 4 | 2015 | Exchanged lanthanum in InHMOR and its impact on the catalytic performance of InHMOR. Spectroscopic, volumetric and microscopic studies | The incorporation of lanthanum by ion exchange into InHMordenite was studied in order to investigate the modification of the physicochemical properties of the InHM catalysts. The prepared solids, LaInHM and InHM, were treated under rigorous reaction conditions, i.e. 25 h of TOS with addition of 10% of water and 500 °C. The structural changes of the catalysts were followed by spectroscopic, volumetric and microscopic studies. The presence of lanthanum in the InHM acts like a protection for the zeolite structure avoiding the formation of EFAl species, but the alteration of the indium environment into the matrix leads to a reduction of the catalytic yield of the InHM catalyst. In fact the XPS results revealed that the concentration of the indium active sites (InO)+ in LaInHM is lower than in the InHM catalyst, while the remaining indium species interact strongly with Lanthanum. After the reaction, a decrease of In active site in the LaInHM catalyst was observed, suggesting a closer interaction In-La which was later corroborated by TEM microscopy. On the other hand, a steric factor between the side channels of the mordenite and the hydrated cation of La during the exchange process locates lanthanum in outer position, with the consequent loss of pore volume and area specific. The lanthanum exchanged ions protect the deactivation process by structure collapse, but negatively affect the activity of the InHM catalyst. | INDIUM-MORDENITE;| NOX-SCR.| LANTHANUM-MORDENITE| ZEOLITE HYDROTHERMAL STABILITY |
| 11 | 1 | 4 | 2015 | Photochemistry of imidazolium cations. Water addition to methylimidazolium ring induced by UV radiation in aqueous solution | The UV-C induced photoaddition of water to N-alkyl-N´-methylimidazolium cations was studied. The main photoreaction products exhibit chemical additions of a proton and a hydroxyl group to either positions 4 or 5 of the imidazolium ring. For unsymmetrical imidazolium cations, two positional isomers were obtained as products. In these cases, the most abundant isomer is the one in which the hydroxyl group adds at the side of the ring having the longer alkyl substituent. Experiments performed in D2O solutions reveal that the additions of proton and hydroxyl group never take place at the same carbon atom, in a reaction that produces equal amounts of diastereoisomers. Moreover, the formation of diastereoisomers at equal proportions suggests that the reaction proceeds in an unconcerted fashion. | Imidazolium|Ionic liquid|photoaddition|UV-C reaction|Water addition |
| 13 | 1 | 4 | 2015 | Soybean fruit development and set at the node level under combined photoperiod and radiation conditions | In soybean, long days during post-flowering increase seed number. This positive photoperiodic effect on seed numberhas been previously associated with increments in the amount of radiation accumulated during the crop cyclebecause long days extend the duration of the crop cycle. However, evidence of intra-nodal processes independent ofthe availability of assimilates suggests that photoperiodic effects at the node level might also contribute to pod set.This work aims to identify the main mechanisms responsible for the increase in pod number per node in responseto long days; including the dynamics of flowering, pod development, growth and set at the node level. Long daysincreased pods per node on the main stems, by increasing pods on lateral racemes (usually dominated positions)at some main stem nodes. Long days lengthened the flowering period and thereby increased the number of openedflowers on lateral racemes. The flowering period was prolonged under long days because effective seed filling wasdelayed on primary racemes (dominant positions). Long days also delayed the development of flowers into pods withfilling seeds, delaying the initiation of pod elongation without modifying pod elongation rate. The embryo developmentmatched the external pod length irrespective of the pod?s chronological age. These results suggest that long daysduring post-flowering enhance pod number per node through a relief of the competition between pods of differenthierarchy within the node. The photoperiodic effect on the development of dominant pods, delaying their elongationand therefore postponing their active growth, extends flowering and allows pod set at positions that are usuallydominated. | Soybean|photoperiod |
| 14 | 1 | 4 | 2015 | Cover crops in the agricultural systems of the Argentine Pampas | Cover crops in the agricultural systems of the Argentine Pampas | COVER CROPS|Pampas Region|NITRATES|Fallow |
| 15 | 1 | 4 | 2015 | Galectin-1 controls the proliferation and migration of liver sinusoidal endothelial cells and their interaction with hepatocarcinoma cells | Galectin-1 (Gal1), a β-galactoside-binding protein abundantly expressed in hepatocellular carcinoma (HCC), promotes epithelial-mesenchymal transition (EMT) and correlates with HCC growth, invasiveness and metastasis. During the early stages of HCC, transforming growth factor β1 (TGF-β1) acts as a tumor suppressor; however in advanced stages, HCC cells lose their cytostatic response to TGF-β1 and undergo EMT. Here, we investigated the role of Gal1 on liver endothelial cell biology, and the contribution and interplay between Gal1 and TGF-β1 in HCC progression. By Western blot and immunofluorescence, we analyzed Gal1 expression, secretion and localization in HepG2 and HuH-7 human HCC cells, and in SK-HEP-1 human liver sinusoidal endothelial cells (SECs). We used loss-of-function and gain-of-function experiments to down- or up-regulate Gal1 expression, respectively, in HepG2 cells. We cultured SK-HEP-1 cells with conditioned media from HCC cells secreting different levels of Gal1, and demonstrated that tumorigenic hepatocyte-derived Gal1 induced its own expression in SECs. MTS colorimetric and scratch-wound assays revealed that secretion of Gal1 by HCC cells induced SEC proliferation and migration, respectively. Interestingly, by fluorescence microscopy we demonstrated that Gal1 promoted glycan-dependent heterotypic adhesion of HepG2 cells to SK-HEP-1 SECs. Furthermore, TGF-β1 induced Gal1 expression and secretion by HCC cells, and promoted HepG2 cell adhesion to SK-HEP-1 SECs through a Gal1 expression-dependent mechanism. Notably, Gal1 modulated HepG2 cell proliferation and sensitivity to TGF-β1-induced growth inhibition. Our results suggest that Gal1 and TGF-β1 might function coordinately within the HCC microenvironment to regulate tumor growth, invasion, metastasis and angiogenesis. | GALECTIN-1|HEPATOCELLULAR CARCINOMA|ENDOTHELIAL CELL|TGF-BETA1 |