| producto_id | tipo_produccion_id | idioma_id | anio_publica | titulo | resumen | palabras_clave |
| 55 | 1 | 5 | 2017 | PENSAR LA LENTIFICACIÓN DE LAS TRAYECTORIAS ESTUDIANTILES UNIVERSITARIAS DESDE LA REFLEXIVIDAD BOURDIANA. UN ESTUDIO SOBRE LA UNIVERSIDAD NACIONAL DE SAN JUAN | El artículo que aquí presentamos, si bien comparte el interés general sobre el devenir de las trayectorias de estudiantes en las instituciones universitarias de gestión estatal, abordado por un número cada vez mayor de estudiosos dedicados al tema, procura desarrollar una visión analítica productiva que permita capturar algunos rasgos de la especificidad del fenómeno en torno a una institución universitaria estatal en particular: la Universidad Nacional de San Juan. Se visibiliza así una línea de investigación que se viene consolidando en la provincia desde hace varios años, espacio académico en el que los autores de este trabajo participan como investigadores.En particular, se trata de analizar el fenómeno de lentificación de las trayectorias académicas estudiantiles. Esto es, cuando el recorrido académico efectuado por los estudiantes universitarios desde su ingreso hasta su graduación o abandono, demanda un tiempo considerablemente superior a lo estipulado según los planes de estudios correspondientes a cada carrera. | Trayectoria |académica|Universidad|Estudiantes |
| 83 | 1 | 4 | 2017 | Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy | Despite the introduction of more than 15 third generation antiepileptic drugs to the market from 1990 to the moment, about one third of the epileptic patients still suffer from refractory of intractable epilepsy. Several hypotheses seek to explain the failure of drug treatments to control epilepsy symptoms in such patients. The most studied one proposes that drug resistance might be related with regional overactivity of efflux transporters from the ATP-Binding Cassette (ABC) superfamily at the blood-brain barrier and/or the epileptic foci in the brain. Different strategies have been conceived to address the transporter hypothesis, among them inhibiting or down-regulating the efflux transporters or bypassing them through a diversity of artifices. Here, we review the computer-assisted early recognition of ABC transporters substrates as an interesting strategy to develop novel antiepileptic drugs capable of treating refractory epilepsy linked to ABC transporters overactivity. | REFRACTORY EPILEPSY|ANTIEPILEPTIC DRUGS|DRUG DISCOVERY|ABC TRANSPORTERS|TRANSPORTER HYPOTHESIS|P-GLYCOPROTEIN|BREAST CANCER RESISTANCE PROTEIN|ABCG2|ABCB1 |
| 111 | 1 | 5 | 2017 | Algoritmos de punto de cambio para la detección de estructuras vorticosas en campos fluidodinamicos turbulentos | En este trabajo se presenta la aplicación y análisis del empleode algoritmos numéricos de modelos para la detección de los cambios enuna señal de flujo turbulento obtenida a partir de medicionesexperimentales, con el objeto de determinar la existencia de estructurasvorticosas presentes en un campo fluidodinamico. Para el estudio de estaaplicación se utilizan mediciones basadas en anemometría de hilocaliente, considerando a las componentes fluctuantes de la velocidad delaire en un punto específico. De la muestra de datos obtenidos se analizala aplicación del modelo de un algoritmo de punto de cambio (CPM), con elfin de determinar los posibles cambios de la fluctuación de la velocidad,comparando los resultados con los análisis tradicionales.Se emplean algoritmos que logran detectar cambios en datos que nopresenten una distribución estadística conocida, como es el caso deseñales de flujo turbulento.Se presentan casos testigos conocidos para lograr establecer laaplicabilidad del algoritmo. Luego se muestra su aplicación a una señalde velocidad correspondiente a desprendimientos periódicos aguas abajo deun dispositivo de control de flujo (mini flap de Gurney) en el borde defuga de un perfil aerodinámicoDe los resultados obtenidos se desprende que el modelo planteado presentauna buena concordancia con las detecciones esperadas, mostrando ser unabuena herramienta alternativa para el análisis de estos tipos deflujo./In this paper the application and analysis of the use of changepoint model algorithms for changes detection in a turbulent flow signalobtained from experimental measurements is presented. In order todetermine the existence of vortex structures in a turbulent flow field.To study this application, hot wire anemometry measurements are used,considering the fluctuating components of velocity of the air at aspecific point. From a data sample a change point model (CPM) algorithmswas applied, in order to determine possible changes of the velocityfluctuation, comparing the results with traditional analysis.Algorithms, to detect changes in data which belongs of a not knownstatistical distribution, such as turbulent flow of signals, are used.Test known cases are presented to establish the applicability of thealgorithm. Then the algorithm is applied to a known periodic detachmentspeed signal downstream a flow control device (mini Gurney flap) in thetrailing edge of an airfoil.From the results it follows that the proposed model shows good agreementwith the expected detections, showing a good alternative tool for theanalysis of these types of flow. | TURBULENCIA|ESCALA TEMPORAL|FRECUENCIA CARACTERISTICA|ALGORITMO DE DETECCION|PUNTO DE CAMBIO |
| 114 | 1 | 4 | 2017 | Estimated population size of two South American sea lion male haulouts from the northern coast of Argentina | Knowledge of the real size of any wild population is an essential tool to take management and conservation measures and even more so when the population studied may have potential conflicts with humans.Because of this, the objective of this study was to estimate the population size of two South American sea lion male haul-outs using mark-resighting techniques. The results showed that on average, the estimated total number of animals tripled the number of animals recorded by direct counting. These findings demonstrate that it is necessary to continue researching population estimate methods to apply when taking conservation measuresin the future. | ARGENTINA|MARK-RESIGHTING|NOREMARK|OTARIA FLAVESCENS|PINNIPEDS|POPULATION ESTIMATES |
| 153 | 1 | 5 | 2017 | El periódico anarquista Nuestra Tribuna. Un diálogo transnacional en América Latina | El presente artículo se inscribe en el marco del fuerte impacto del enfoque transnacional en la historiografía de América Latina y en los estudios sobre el anarquismo. Particularmente, sigue la línea de los trabajos que analizan la prensa anarquista como soporte de las redes trasnacionales. Un objetivo más específico está relacionado con el caso particular del periódico Nuestra Tribuna. | ANARQUISMO|PRENSA ANARQUISTA|REDES TRANSNACIONALES|AMÉRICA LATINA |
| 160 | 1 | 4 | 2017 | Methodology for the estimation of the age categories of Hydrochoerus hydrochaeris (Rodentia, Hydrochoeridae) through the cranial and femur morphometry | The aim of this study is to propose a methodologyto estimate the age of individuals of capybaras(Hydrochoerus hydrochaeris) using some morphometricmeasurements of the skull and femur. A sample of 250individuals from different age categories was analyzed.These categories were estimated based on the ossificationdegree of the cranial sutures. Out of 28 morphocranialmeasurements taken, nine of them allow us to adequatelydetermine the degree of bone maturation and the relativeage: pre maxillonasal maximum width (MNW), pre maxillonasalminimum width (MNMW), parietal width (PW),intermaxillary width (IMW), maximum width of the 3rdmolar (MW), minimum width of the 3rd molar (MMW),3rd molar length (M3), molar length, and molar 1 and 2length (M12). In case of the femur, the measurements didnot show differences among age categories, thus, we discardedthese morphometric magnitudes as possible ageindicators. This work proposes new measures to estimateand to analyze the relative age structure of the capybarapopulation, providing a useful tool in the management and conservation of this species, and to evaluate paleontologicaland archaeological assemblages. | Age estimation|Capybara|Morphometric measurements|Skulls |
| 178 | 1 | 4 | 2017 | Forbidden induced subgraphs of normal Helly circular-arc graphs: Characterization and detection | A normal Helly circular-arc graph is the intersection graph of a set of arcs on a circle of which no three or less arcs cover the whole circle. Lin et al. (2013) characterized circular-arc graphs that are not normal Helly circular-arc graphs, and used them to develop the first recognition algorithm for this graph class. As open problems, they ask for the forbidden subgraph characterization and a direct recognition algorithm for normal Helly circular-arc graphs, both of which are resolved by the current paper. Moreover, when the input is not a normal Helly circular-arc graph, our recognition algorithm finds in linear time a minimal forbidden induced subgraph as a certificate. Our approach yields also a considerably simpler algorithm for the certifying recognition of proper Helly circular-arc graphs, a subclass of normal Helly circular-arc graphs. | Certifying algorithms|Linear-time; (proper) interval graphs|Chordal graphs; (minimal) forbidden induced subgraphs|Holes; (normal, Helly, proper) circular-arc models |
| 183 | 1 | 4 | 2017 | The maximum-impact coloring polytope | Given two graphs $G=(V,E_G)$ and $H=(V,E_H)$ over the same set of vertices and given a set of colors $C$, the emph{impact on $H$} of a coloring $c:Vo C$ of $G$, denoted $imp(c)$, is the number of edges $ijin E_H$ such that $c(i) = c(j)$. In this setting, the emph{maximum-impact coloring} problem asks for a proper coloring of $G$ maximizing the impact $imp(c)$ on $H$. This problem naturally arises in the assignment of classrooms to courses, where it is desirable --but not mandatory-- to assign lectures from the same course to the same classroom. Since the maximum-impact coloring problem is NP-hard, we propose in this work an integer-programming-based approach for tackling this problem. To this end, we present an integer programming formulation and we study the associated polytope. We provide several families of valid inequalities, and we study under which conditions these inequalities define facets of the associated polytope. Finally, we show computational evidence over real-life instances suggesting that some of these families may be useful in a cutting-plane environment. | coloring|integer programming|facets |
| 218 | 1 | 5 | 2017 | Naturales, vecinos y extranjeros en el ejercicio de cargos públicos y oficios. Buenos Aires (ciudad y campaña), 1812-1815 | En este artículo nos proponemos analizar la situación jurídica y política de los extranjeros que ocupaban cargos públicos y ejercían oficios en el Río de la Plata entre 1812 y 1815, a partir de documentos originales de la época. Demostramos que los derechos del natural y de vecino fueron los principales ejes sobre los que se continuaron planteando las prácticas políticas. En Buenos Aires, las cartas de ciudadanía se otorgaban discrecionalmente según lo resuelto por las autoridades y de acuerdo con las necesidades de la revolución. | Ciudadanía|Revolución de Mayo|Naturaleza|Cargos Públicos |
| 290 | 1 | 4 | 2017 | Current State and Future Perspectives in QSAR Models to Predict Blood Brain Barrier penetration in Central Nervous System Drug R&D | The blood brain barrier (BBB) is a physical and biochemical barrier that restricts the entry of certain drugs to the Central Nervous System (CNS), while allowing the passage of others. The ability to predict the permeability of a given molecule through the BBB is a key aspect in CNS drug discovery and development, since neurotherapeutic agents with molecular targets in the CNS should be able to cross the BBB, whereas peripherally acting agents should not, to minimize the risk of CNS adverse effects. In this review we examine and discuss QSAR approaches and current availability of experimental data for the construction of BBB permeability predictive models, focusing on the modeling of the biorelevant parameter unbound partitioning coefficient (Kp,uu). Emphasis is made on two possible strategies to overcome the current limitations of in silico models: considering the prediction of brain penetration as a multifactorial problem, and increasing experimental datasets through accurate and standardized experimental techniques. | QSAR|IN SILICO MODELS|BBB|Kpuu|BRAIN PENETRATION|CENTRAL NERVOUS SYSTEM |